At Westlake High School, Foles was a two-year starter at quarterback. He threw for 5,658 yards and 56 touchdowns. Both of those were new school records, formerly held by Drew Brees. Foles was teammates with Baltimore Ravens kicker Justin Tucker.

Foles was also a standout in basketball. He was recruited by Georgetown, Baylor, and Texas. Foles originally committed to Arizona State but later decided to change his mind and attend Michigan State.

Nick Foles began his college football career at Michigan State. After one year, he transferred to Arizona and had to redshirt for the 2008 season. Foles began his first year in Arizona after his redshirt season as a backup to Matt Scott. After Scott struggled in a game against Iowa, Foles became the new starter. Foles finished the season with 2,486 passing yards with 19 touchdowns and nine interceptions.

In 2010, Foles was a redshirt junior. He led Arizona to a 7-1 start to the season before a knee injury knocked him out for two games. He finished the season with 3,191 yards, 20 touchdowns, and 10 interceptions. In his final season in 2011, Foles had his best statistical season. He completed 387 of 560 passes (69.1%) and threw for 4,334 yards and 28 touchdowns.

Nick Foles was drafted by the Philadelphia Eagles in the third round of the 2012 NFL Draft with the 88th overall pick. Foles made his first career start in Week 11 of the 2012 season when Michael Vick was sidelined due to injury. He was eventually named the starter for the rest of the year but broke his hand on December 23rd and missed the rest of the season. 

Foles started the 2013 season backing up Vick once again. In Week 6, Foles got the starting nod again with another Vick injury. He earned NFC Offensive Player of the Week honors that week. The following week, Foles suffered a concussion that kept him out till Week 9. He finished the season as the starter, ending with 27 touchdowns and just two interceptions. 

In 2014, Foles suffered a broken collarbone in Week 9 that ended his season. Following the season, Foles was traded to the St. Louis Rams. After a good start to his St. Louis' career, Foles began to struggle and ultimately lost the starting job to Case Keenum (twice). After the Rams used the first overall pick to draft Jared Goff, Foles asked to be released. 

Foles signed a one-year deal worth $1.75 million with the Kansas City Chiefs on August 3, 2016. He started two games while Alex Smith was out with a concussion. The Chiefs declined his second-year option. In March of 2017, Foles signed a two-year deal to return to Philadelphia. 

Foles served as the backup to Carson Wentz. Wentz tore his ACL in Week 14, opening the door for Foles to be the Eagles’ starter for the rest of the season. Foles led the Eagles to their first playoff win in nine seasons. He had his best playoff performance in the NFC Championship Game against Minnesota and the league’s best defense. He threw for 352 yards and three touchdowns. 

In Super Bowl LII, Foles caught a touchdown pass on what became known as “The Philly Special”. Foles became the first player in history to catch and throw a touchdown pass in the Super Bowl. Foles went 28 of 43 for 373 yards, three touchdowns, and one interception. He was named Super Bowl MVP. Foles was the starter for the beginning of the 2018 season as Wentz was not cleared yet. In Week 3, Wentz regained his starting role. Foles got a couple more starts at the end of the season, even breaking Donovan McNabb’s single-game franchise passing record with 471 yards. Following the 2019 season, Foles elected to opt out of his contract and become a free agent. 

In March of 2019, Foles signed a four-year deal with the Jacksonville Jaguars worth $88 million. In Week 1, Foles suffered a broken collarbone that sidelined him for two months. However, Gardner Minshew eventually overtook Foles starting job. He finished the season with just four starts (3TD 2INT). 

On March 31, 2020, Foles was traded to the Chicago Bears. Foles started the season as the backup to Mitchell Trubisky. However, he won the starting job in Week 3 when he led a comeback win against the Atlanta Falcons. Foles finished the season with a 2-5 record as Chicago’s starter. The quarterback threw for 1,852 yards, 10 touchdowns, eight interceptions and an 80.8 passer rating.

Since the start of the 2021 season, Foles has returned to being a backup. Foles made one start during his final year with the Bears before being released. The Indianapolis Colts signed Foles for the 2022 season. Foles went 0-2 in two starts late in the season after both Matt Ryan and Sam Ehlinger were benched. The former Super Bowl MVP struggled with no touchdowns and four interceptions.