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Chicago Cubs vs St. Louis Cardinals Predictions

July 27 07:45 PM (Start in 3 Hours)
MARQ Busch Stadium

Cubs vs. Cardinals Matchup Overview

The Chicago Cubs visit Busch Stadium to take on the St. Louis Cardinals on July 27th, 2026 at 7:45 pm. The Cubs hold a record of 59-45, while the Cardinals sit at 53-51. Check out the current betting odds with the Cubs at -116 on the moneyline and the Cardinals at -104. The Edge AI sports betting tool can help you find the best bets for this matchup. Key players for the Cubs include Pete Crow-Armstrong, who boasts a .290 batting average with 23 home runs and 60 RBIs, and Seiya Suzuki, hitting .265 with 18 home runs. For the Cardinals, Alec Burleson is hitting .289 with 15 home runs and 71 RBIs, while Jordan Walker brings a solid .286 average with 22 home runs. Both teams are relatively healthy, with no significant injuries reported. In their recent matchups, the Cubs have won two of the last three games against the Cardinals, making this a competitive series.

Matchup Overview

  • Teams: Chicago Cubs vs St. Louis Cardinals
  • Date: Monday, July 27, 2026
  • Time: 7:45 PM
  • Venue: Busch Stadium

Current Betting Odds

  • Spread: Cubs +1.5 (+134) (-1.5 (+135 )), Cardinals +1.5 (-165) (+1.5 (-162 BetMGM Sportsbook))
  • Total (Over/Under): 9.5 (-112/-112) (Over 9.5 (-110 BetMGM Sportsbook), Under 9.5 (-110 BetMGM Sportsbook))
  • Moneyline Odds: Cubs -116 (-110 (BetMGM Sportsbook)), Cardinals -104 (-103 ())

Edge AI Win Probabilities

After 1,000 simulations, our model gives the Cubs a win probability of 51%, while the Cardinals have a win probability of 49%

The Cubs and Cardinals have a long-standing rivalry that dates back over a century, with the Cardinals historically holding the edge in their all-time record. The Cubs are known for their power-hitting style, while the Cardinals typically emphasize a balanced approach with solid pitching. When these teams meet, the home field advantage at Busch Stadium often plays a significant role, influencing outcomes and betting trends in this classic matchup.

Projected Final Score

Our Edge AI predicts a final score of Cubs 5-4 Cardinals with a confidence score of 65%. These projections are based on 1,000 simulations and hundreds of data points, ensuring you have the most accurate predictions to inform your betting strategy.

Point Spread
51%
49%
Confidence Level: 72.1%

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Over/Under
51%
49%
Confidence Level: 58.7%

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Moneyline
51%
49%
Confidence Level: 65.4%

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When the Cubs and Cardinals face off, it’s more than just a game; itโ€™s a classic rivalry steeped in history. The Cubs often lean on their power hitters, while the Cardinals typically showcase a balanced attack with solid pitching, making for a compelling contrast. Historically, St. Louis tends to have the upper hand at home, but the Cubs’ lineup can swing the momentum in their favor, leading to interesting money line shifts as bettors react to these dynamics.

Chicago Cubs vs St. Louis Cardinals Moneyline

The Cubs, sitting at 59-45, are slight favorites on the moneyline against the Cardinals, who are 53-51. With Pete Crow-Armstrong and Seiya Suzuki leading Chicago’s offense, they could capitalize on St. Louis’ pitching struggles, making this matchup one to watch for bettors considering their options.

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Chicago Cubs vs St. Louis Cardinals Run Line

The Chicago Cubs, with a solid road record, could have an edge on the run line against the St. Louis Cardinals. However, St. Louis, backed by a strong home offense, might keep the game close enough to challenge that spread. Starting pitchers and recent form will be key factors in determining the margin.

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Chicago Cubs vs St. Louis Cardinals Over/Under

The Cubs and Cardinals have been averaging around 9.5 runs in their recent matchups, reflecting solid offensive capabilities from both sides. With key hitters like Pete Crow-Armstrong and Alec Burleson in form, the potential for scoring is there, but the effectiveness of each team’s pitching staff could play a significant role in determining the total runs in this game.

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59-46
All
53-52
30-22
Home
27-29
29-24
Away
26-23
47-33
as Fav
22-21
12-13
as Dog
31-31
46-59
ATS
55-50
19-33
ATS Home
26-30
27-26
ATS Away
29-20
56-48
O/U
42-58
28-24
O/U Home
22-33
28-24
O/U Away
20-25
RESULT
WIN 10-3
DATE
06/24
SPREAD
-1.5
O/U
o8.5
RESULT
LOSE 5-6
DATE
04/05
SPREAD
-1.5
O/U
o7.5
RESULT
LOSE 7-8
DATE
07/26
SPREAD
โ€”
O/U
o8.5
RESULT
WIN 11-0
DATE
07/25
SPREAD
โ€”
O/U
o7.5
RESULT
WIN 3-2
DATE
07/24
SPREAD
-1.5
O/U
u8.0
RESULT
LOSE 10-6
DATE
07/23
SPREAD
-1.5
O/U
o8.5
RESULT
WIN 8-1
DATE
05/23
SPREAD
โ€”
O/U
u9.5
RESULT
LOSE 4-3
DATE
07/07
SPREAD
+1.5
O/U
u8.0
RESULT
LOSE 5-3
DATE
07/26
SPREAD
โ€”
O/U
u8.5
RESULT
WIN 0-7
DATE
07/25
SPREAD
โ€”
O/U
u8.5
WHO WON
Cubs logo CHC
RESULT
4-6
DATE
07/05
WHO WON
Cardinals logo STL
RESULT
3-0
DATE
07/04
WHO WON
Cardinals logo STL
RESULT
17-1
DATE
07/03
WHO WON
Cardinals logo STL
RESULT
1-5
DATE
05/31
WHO WON
Cubs logo CHC
RESULT
6-1
DATE
05/30

BOX SCORE: MLB TEAM STATS & PLAYER STATS

0
At Bats
0
0
Runs
0
0
Hits
0
0
Walks
0
0
Strikeouts
0
0.339
On Base Percentage
0.316
0.414
Slugging Percentage
0.381
4.23
Earned Run Average
4.14
0
Earned Runs
0
0
Home Runs
0
0
Walks
0
0
Strikeouts
0
0
Strikeouts Per 9 Innings
0
1.27
Walks Plus Hits Per Inning Pitched
1.33
Batters
AVG
HR
RBI
H
0.247
4
44
102
0.234
10
44
94
0.290
23
60
114
0.247
13
56
96
0.220
18
45
82
0.220
16
61
76
0.265
18
58
89
0.257
6
36
62
0.237
9
24
37
0.239
3
17
34
0.305
1
13
25
0.286
0
3
2
Starting pitcher
W-L
ERA
WHIP
K
5-7
5.97
1.56
74
Pitchers
W-L
ERA
WHIP
K
7-8
3.72
1.10
113
7-7
4.86
1.42
81
5-7
5.97
1.56
74
6-1
3.86
1.12
42
6-1
3.81
1.24
55
3-2
2.84
1.31
51
5-1
2.70
1.30
40
3-2
4.07
1.23
40
3-3
2.61
1.03
15
0-0
2.08
1.23
13
0-1
7.11
1.03
16
0-2
10.45
1.94
8
0-0
18.00
2.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
full roster
Batters
AVG
HR
RBI
H
0.289
15
71
116
0.286
22
77
114
0.253
15
40
99
0.244
12
44
94
0.238
4
42
83
0.225
8
30
59
0.253
4
21
45
0.207
4
11
31
0.241
3
15
32
0.238
1
22
25
0.182
3
9
14
0.213
4
11
16
Starting pitcher
W-L
ERA
WHIP
K
5-7
5.18
1.52
95
Pitchers
W-L
ERA
WHIP
K
4-8
3.07
1.13
74
11-6
3.77
1.21
83
5-7
4.59
1.32
103
7-4
3.55
1.34
88
5-7
5.18
1.52
95
6-1
3.16
1.13
32
0-0
3.83
1.40
34
3-3
3.50
1.10
43
1-3
3.35
1.30
43
2-3
7.23
1.72
40
3-4
3.67
1.22
44
1-2
2.70
1.35
20
0-0
5.00
1.33
8
0-0
0.00
1.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
0-0
0.00
0.00
0
full roster