New York Giants vs. San Francisco 49ers Game Pick

The New York Giants take on the San Francisco 49ers at Levi's Stadium on Thursday, September 21st, at 8:15 PM EDT

New York Giants vs. San Francisco 49ers Odds

Moneyline: Giants +400 (FanDuel), 49ers -450 (PointsBet)

Point Spread: Giants +10.5 (-110 FanDuel), 49ers -10.0 (-109 BetRivers)

Total: Over 44.5 (-110 FanDuel), Under 45.0 (-109 BetRivers)

Betting Trends

ATS: Giants: 0-2 49ers: 2-0

Over/Under: Giants: 1-1 49ers: 1-1

Matchup Preview

In a matchup between the New York Giants and the San Francisco 49ers, both teams are coming off contrasting starts to the season. The Giants have struggled on offense, with quarterback Daniel Jones throwing three interceptions in two games. Running back Saquon Barkley will miss this game with an ankle injury. The 49ers have started the season strong, with a balanced offense led by quarterback Brock Purdy. Their defense has been solid, keeping opponents in check. With injuries and inconsistent play, the Giants face an uphill battle on the road.

Spread Pick: San Francisco