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New York Giants vs. San Francisco 49ers Over/Under 09/21/2023

New York Giants

4-13

FINAL

12-30

AMZN

Levi's Stadium

San Francisco 49ers

12-5

New York Giants vs. San Francisco 49ers Game Pick

The New York Giants take on the San Francisco 49ers at Levi’s Stadium on Thursday, September 21st, at 8:15 PM EDT

New York Giants vs. San Francisco 49ers Odds

Moneyline: Giants +400 (FanDuel), 49ers -450 (PointsBet)

Point Spread: Giants +10.5 (-110 FanDuel), 49ers -10.0 (-109 BetRivers)

Total: Over 44.5 (-110 FanDuel), Under 45.0 (-109 BetRivers)

Betting Trends

ATS: Giants: 1-1 49ers: 2-0

Over/Under: Giants: 1-1 49ers: 2-0

Matchup Preview

The New York Giants have struggled on offense and will be without Saquon Barkley. On the other side, the 49ers will look to quarterback Brock Purdy to lead their offense. With both teams dealing with injuries, it will be a challenging game in terms of scoring.

Total Pick: Under

NFL Computer Pick Overunder

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