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San Francisco 49ers vs. Buffalo Bills Point Spread 12/01/2024

FINAL
10-35
NBC
Highmark Stadium
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San Francisco 49ers vs. Buffalo Bills GAME PICK

The San Francisco 49ers take on the Buffalo Bills December 1st, 2024 at Highmark Stadium at 8:20 pm

San Francisco 49ers vs. Buffalo Bills ODDS

  • Moneyline: 49ers +265 (FanDuel), Bills -310 (DraftKings)
  • Point Spread: 49ers +7.0 (-105 Caesars Casino), Bills -6.5 (-120 FanDuel)
  • Total: Over 44.5 (-110 Caesars Casino), Under 44.5 (-107 BetRivers)

BETTING TRENDS

  • Record: 49ers: 5-6 Bills: 9-2
  • ATS: 49ers: 4-7 Bills: 7-4
  • Over/Under: 49ers: 6-5 Bills: 7-4

MATCHUP PREVIEW

The San Francisco 49ers are set to clash with the Buffalo Bills at Highmark Stadium on December 1st, 2024, at 8:20 PM. The 49ers, with a 5-6 record, face a daunting challenge against the 9-2 Bills, who have demonstrated superior form this season. Brock Purdy leads the 49ers with a solid 2,613 passing yards, but his questionable status due to limited practice raises concerns. The 49ers’ roster is riddled with injuries, including key players like Trent Williams and Nick Bosa, which could significantly impact their performance. On the other hand, the Bills, under the leadership of Josh Allen, boast impressive offensive stats, with Allen throwing for 2,543 yards and 18 touchdowns. The Bills have a healthier roster, with most players likely to participate, giving them a considerable edge. The Bills’ strong defensive efficiency combined with their offensive prowess makes them formidable opponents. Given the 49ers’ injury woes and the Bills’ consistent performance, Buffalo is poised to dominate this matchup.

NFL Computer Pick
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Lines.com 11/24 12:36

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