The San Francisco 49ers take on the Buffalo Bills at Highmark Stadium on Sunday, December 1st, at 8:20 PM EST
Moneyline: 49ers +260 (Caesars Casino), Bills -275 (BetMGM)
Point Spread: 49ers +7.0 (-110 Caesars Casino), Bills -6.5 (-115 BetRivers)
Total: Over 46.0 (-110 Caesars Casino), Under 46.5 (-113 BetRivers)
Record: San Francisco 49ers: 5-6 Buffalo Bills: 9-2
ATS: San Francisco 49ers: 4-7 Buffalo Bills: 7-4
Over/Under: San Francisco 49ers: 6-5 Buffalo Bills: 7-4
In a clash between the 5-6 49ers and the 9-2 Bills, injuries plague the 49ers’ key players, creating a challenging matchup. The absence of Brock Purdy, Nick Bosa, and others may hinder the 49ers’ performance. On the other hand, the Bills, led by Josh Allen, have shown consistency and strength with a 9-2 record. Expect the Bills to capitalize on the 49ers’ vulnerabilities and secure a victory in this game. Our pick: over
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