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San Francisco 49ers vs. Buffalo Bills Over/Under 12/01/2024

FINAL
10-35
NBC
Highmark Stadium
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San Francisco 49ers vs. Buffalo Bills GAME PICK

The San Francisco 49ers take on the Buffalo Bills December 1st, 2024 at Highmark Stadium at 8:20 pm

San Francisco 49ers vs. Buffalo Bills ODDS

  • Moneyline: 49ers +265 (FanDuel), Bills -310 (DraftKings)
  • Point Spread: 49ers +7.0 (-105 Caesars Casino), Bills -6.5 (-120 FanDuel)
  • Total: Over 44.5 (-110 Caesars Casino), Under 44.5 (-107 BetRivers)

BETTING TRENDS

  • Record: 49ers: 5-6 Bills: 9-2
  • ATS: 49ers: 4-7 Bills: 7-4
  • Over/Under: 49ers: 6-5 Bills: 7-4

MATCHUP PREVIEW

In a highly anticipated matchup at Highmark Stadium, the San Francisco 49ers face the Buffalo Bills. The 49ers, struggling with a 5-6 record, are dealing with significant injuries, particularly on their offensive line and defensive front. Brock Purdy’s status is questionable, adding uncertainty to their offensive capabilities. Despite Purdy’s solid performance with 2,613 yards and 13 touchdowns, the potential absence of key players like Trent Williams and Nick Bosa could hinder both offensive protection and defensive pressure. The Bills, with a strong 9-2 record, have shown consistency and resilience. Josh Allen leads a potent offense, boasting 2,543 passing yards and 18 touchdowns. James Cook adds versatility with 10 rushing touchdowns, complementing Allen’s aerial attack. Buffalo’s defense has been formidable, and with fewer injury concerns compared to the 49ers, they have the upper hand. Given the 49ers’ injury woes and the Bills’ home-field advantage, expect Buffalo to capitalize on San Francisco’s vulnerabilities. This game is likely to see a competitive scoreline, but Buffalo’s balanced attack and defensive strength should prevail.

NFL Computer Pick
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Lines.com 11/24 12:36

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