New York Giants vs. San Francisco 49ers Game Pick

The New York Giants take on the San Francisco 49ers at Levi's Stadium on Thursday, September 21st, at 8:15 PM EDT

New York Giants vs. San Francisco 49ers Odds

Moneyline: Giants +400 (FanDuel), 49ers -450 (PointsBet)

Point Spread: Giants +10.5 (-110 FanDuel), 49ers -10.0 (-109 BetRivers)

Total: Over 44.5 (-110 FanDuel), Under 45.0 (-109 BetRivers)

Betting Trends

ATS: Giants: 1-1 49ers: 2-0

Over/Under: Giants: 0-2 49ers: 0-2

Matchup Preview

In a Week 3 matchup, the New York Giants will face off against the San Francisco 49ers. The Giants will rely on quarterback Daniel Jones, who has thrown for 425 yards, 2 touchdowns, and 3 interceptions so far this season. The Giants will be missing star running back Saquon Barkley. On the other side, the 49ers have a perfect 2-0 record and will look to continue their success. With their strong defense and efficient offense, led by quarterback Brock Purdy, the 49ers are favored to win this game.

Moneyline Pick: San Francisco