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San Francisco 49ers vs. Buffalo Bills MoneyLine 12/01/2024

FINAL
10-35
NBC
Highmark Stadium
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San Francisco 49ers vs. Buffalo Bills GAME PICK

The San Francisco 49ers take on the Buffalo Bills December 1st, 2024 at Highmark Stadium at 8:20 pm

San Francisco 49ers vs. Buffalo Bills ODDS

  • Moneyline: 49ers +265 (FanDuel), Bills -310 (DraftKings)
  • Point Spread: 49ers +7.0 (-105 Caesars Casino), Bills -6.5 (-120 FanDuel)
  • Total: Over 44.5 (-110 Caesars Casino), Under 44.5 (-107 BetRivers)

BETTING TRENDS

  • Record: 49ers: 5-6 Bills: 9-2
  • ATS: 49ers: 4-7 Bills: 7-4
  • Over/Under: 49ers: 6-5 Bills: 7-4

MATCHUP PREVIEW

The San Francisco 49ers take on the Buffalo Bills in a primetime showdown at Highmark Stadium. The 49ers, coming off a challenging season with a 5-6 record, face a formidable 9-2 Bills team. Buffalo’s Josh Allen has been impressive, boasting 2,543 passing yards and 18 touchdowns with only 5 interceptions. Meanwhile, Brock Purdy has thrown for 2,613 yards and 13 touchdowns but faces uncertainty as he is listed as questionable. The 49ers are dealing with significant injury concerns, including key players like Nick Bosa and Trent Williams. Their defense, which has struggled at times, will need to step up against a Bills offense that ranks high in efficiency. Buffalo’s defense, though not as efficient as their offense, has been solid and could capitalize on San Francisco’s vulnerabilities. With the Bills’ strong performance this season and the 49ers’ injury woes, Buffalo is poised to take advantage of their home-field advantage and maintain their winning momentum.

NFL Computer Pick
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Lines.com 11/24 12:36

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