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NFL Betting Preview: San Francisco 49ers vs. Arizona Cardinals

The Arizona Cardinals (0-0) are 7.5-point underdogs in a home NFC West matchup against the San Francisco 49ers (0-0) on Sunday, September 13, 2020 Levi's Stadium. The contest has an over/under of 45.0.

Game Info

  • Game Day: Sunday, September 13, 2020
  • Game Time: 4:25 PM
  • TV Channel: FOX
  • Location: Santa Clara, CA
  • Stadium: Levi's Stadium
  • 49ers Players to Watch

  • Jimmy Garoppolo recorded 3,979 passing yards (248.7 yards per game) with a 69.1% completion percentage last year (329-of-476), while throwing 27 touchdowns and 13 interceptions in 16 games.
  • Raheem Mostert took 137 attempts for 772 rushing yards a season ago (48.3 yards per game) while scoring eight touchdowns in 16 games.
  • Tevin Coleman totaled 544 rushing yards on 137 carries (38.9 yards per game), with six touchdowns on the ground over the course of 14 games in 2019.
  • George Kittle hauled in 85 passes for 1,053 yards last season with five touchdowns. He was targeted 107 times and averaged 75.2 yards per game over 14 outings.
  • Kendrick Bourne's statline last year showed 30 catches for 358 yards and five touchdowns in 16 games. He put up 22.4 receiving yards per game and was targeted 45 times.
  • Kyle Juszczyk caught 20 passes on 24 targets for 239 yards and one touchdown, averaging 19.9 yards per game in 12 contests in 2019.
  • Arik Armstead put together an impressive statline of 10.0 sacks, 11.0 TFL and 54 tackles over 16 games.
  • In 16 games over his 2019 campaign, Fred Warner totaled 118 tackles, 7.0 TFL, three sacks, and one interception.
  • Richard Sherman intercepted three passes while adding 60 tackles, 2.0 TFL, and 11 passes defended over 15 games a season ago.
  • Cardinals Players to Watch

  • Kyler Murray collected 3,722 passing yards (232.6 yards per game) with a 64.4% completion percentage last year (349-of-542), while throwing 20 touchdowns and 12 interceptions in 16 games. He also added 544 rushing yards on 93 carries with four touchdowns, averaging 34.0 yards per game.
  • Kenyan Drake took 171 attempts for 823 rushing yards a season ago (58.8 yards per game) while scoring eight touchdowns in 14 games. He also caught 50 passes for 345 yards (24.6 receiving yards per game).
  • Murray totaled 544 rushing yards on 93 carries (34.0 yards per game), with four touchdowns on the ground over the course of 16 games in 2019.
  • Last season, DeAndre Hopkins hauled in 104 passes (on 150 targets) for 1,165 yards (77.7 yards per game) with seven touchdowns in 15 games.
  • Larry Fitzgerald also chipped in with 804 yards on 75 grabs with four touchdowns. He was targeted 109 times and averaged 50.3 receiving yards per game in 16 matchups last year.
  • Over 13 games in 2019, Christian Kirk caught 68 passes on 108 targets for 709 yards and three touchdowns, averaging 54.5 receiving yards per game.
  • Chandler Jones had a strong body of work a year ago, notching 19.0 sacks, 11.0 TFL and 55 tackles over 16 games.
  • Jordan Hicks racked up 148 tackles, 11.0 TFL, 1.5 sacks, and three interceptions in 16 games over the course of his 2019 campaign.
  • 49ers vs Cardinals: Last 5 Meetings

  • In the past five meetings, Arizona has a 3-2 record against San Francisco.
  • Arizona has scored 117 points in the last five meetings while only allowing 107 to San Francisco
  • 49ers vs Cardinals: Last Five Meetings
    Date Home Team Total Yards Result
    11/17/2019 49ers 442-266 SF 36-26 SF
    10/31/2019 Cardinals 411-357 SF 28-25 SF
    10/28/2018 Cardinals 321-267 ARI 18-15 ARI
    10/7/2018 49ers 447-220 SF 28-18 ARI
    11/5/2017 49ers 368-329 ARI 20-10 ARI

    49ers Team Data

  • The 49ers averaged points scored last season (29.9) and the Cardinals points allowed (27.6) were within 2.3 points of each other.
  • When they met or went over their scoring average last season, San Francisco was 8-0.
  • Arizona was 4-3-1 last season in games where they allowed fewer than 27.6 points.
  • The 49ers offense racked up 20.9 fewer yards than the Cardinals defense surrendered last season (381.1 to 402).
  • When the San Francisco offense put together a game with at least their 2019 average in yardage, they were 8-0 last season.
  • Arizona was 4-2 last season when their defense allowed fewer yards than their season average.
  • The Cardinals allowed opposing rushing attacks to average 120.1 yards per game in 2019 compared to the 144.1 yards the 49ers offense averaged on the ground per contest.
  • When San Francisco rushers gained at least a combined 144.1 yards, they had a record of 5-1 last season.
  • Last season, when the Arizona defense allowed opponents to pick up less than 120.1 yards on the ground, they were 4-5-1.
  • Last season, the Cardinals forced an average of 1.1 turnovers per game compared to the 1.4 times 49ers turned the football over in each contest.
  • When San Francisco turned the football over 1.4 times or fewer last season they were 8-1.
  • Arizona was 2-3-1 last season when they forced at least 1.1 turnovers in a game.
  • Cardinals Team Data

  • The Cardinals averaged 3.2 more points per game last year (22.6) than the 49ers gave up (19.4).
  • Arizona finished 5-4-1 overall a season ago when the team scored at least 22.6 points.
  • Last season, San Francisco had an 8-0 record in games when it held opponents to 29.9 or fewer points.
  • The Cardinals racked up 341.7 yards per game in 2019, 59.4 more yards than the 282.3 the 49ers allowed per outing.
  • When the San Francisco offense put together a game with at least their 2019 average in yardage, they were 8-0 last season.
  • San Francisco had a 7-0 record last year when holding its opponents to 282.3 yards or less.
  • Last season, the Cardinals piled up 124.4 rushing yards per game, 11.8 more per game than the 49ers allowed per outing (112.6).
  • Last year, Arizona put together a 4-2 record in games the team ran for at least 124.4 yards.
  • When San Francisco limited its opponents to 112.6 yards on the ground or less last season, it finished 6-1.
  • The Cardinals turned the ball over 1.1 times per game last year, just 0.6 fewer turnovers per game than the 1.7 the 49ers forced on average.
  • In games in 2019, Arizona finished with a 5-5-1 record when it turned the ball over 1.1 times or less.
  • San Francisco compiled a 5-1 record when it forced at least 1.7 turnovers last season.
  • 49ers Fantasy Leaders

  • Garoppolo was the No. 18 fantasy player overall and the No. 14 fantasy quarterback in 2019 with 247.4 points (averaging 15.5 per game).
  • Mostert collected total 151.2 fantasy points last season (9.5 per game), which made him the 66th-ranked player overall and the 20th-ranked running back.
  • Last year, Kittle averaged 9.8 fantasy points per game on the way to 137.5 total fantasy points. That made him the 80th-ranked fantasy player overall and the third-ranked tight end.
  • Coleman was the 104th-ranked fantasy player -- and the 32nd-ranked running back -- in 2019 with 114.4 fantasy points. He averaged 8.2 fantasy points per game.
  • Cardinals Fantasy Leaders

  • Murray's productive 2019 fantasy season earned him the No. 9 spot overall and the No. 8 spot among QBs. He put up 285.3 fantasy points on the year (17.8 per game).
  • Drake collected 164.8 fantasy points (11.8 per game) last year to be the 56th-ranked player overall and the 18th-ranked running back.
  • Hopkins was the No. 10 wide receiver and the No. 57 fantasy player overall with 164.5 total points last season (11.0 per game).
  • Fitzgerald's 2019 campaign saw him finish as the No. 117 fantasy player and the No. 42 WR with 102.4 fantasy points (averaging 6.4 per game).
  • Betting Information

    49ers vs Cardinals Betting Information
    Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
    49ers -7.5 -110 -110 45.0 -110 -110 -370 295

    49ers Betting Insights

  • San Francisco had an 8-6 record against the spread last year.
  • Last season, the 49ers had an ATS record of 1-3 when favored by 7.5 points or more.
  • In 2019, the majority of San Francisco's games with a betting line -- five out of 14 opportunities -- went over the point total (35.7%).
  • 49ers Home Trends

  • San Francisco hit the over in just five out of eight home games last year with a point total prop bet (62.5%).
  • Last season, 49ers home games averaged 52 points, 7.0 more than this outing's over/under (45.0).
  • San Francisco compiled an even 4-4 record against the spread at home last year, and went 6-2 overall in home games.
  • The 49ers went 1-1 ATS in home games last season when favored by at least 7.5 points.
  • Cardinals Betting Insights

  • Most of Arizona's games with a betting line last year -- eight out of 14 opportunities -- went over the point total (57.1%)
  • Arizona had a 7-6-1 record against the spread last year.
  • Cardinals Road Trends

  • Arizona finished with a 4-2-1 record against the spread on the road last year, and went 3-5 overall in away games.
  • Arizona hit the over four times in eight opportunities on the road last year (50%).
  • Last season, Cardinals away games averaged 48.9 points, 3.9 more than this contest's over/under (45.0).
  • Additional Info

  • The average total in 49ers matchups last season was 49.3, 4.3 more points than the over/under for this game.
  • Cardinals matchups last year had a 50.2-point average over/under, 5.2 more points than this game's total.
  • Last season, San Francisco played in nine games that finished with a point total higher than 45.0 (56.2% of matchups).
  • Arizona's games went over 45.0 points nine times last year (56.2% of matchups).
  • The two teams combined to score 52.5 points per game last season, 7.5 more points than this matchup's total.
  • Combined, these teams gave up 47 points per contest last year, 2.0 more points than the total for this game.
  • Injury Report

    49ers: Ben Garland: Questionable (Ankle), Jason Verrett: Out (Hamstring), Brandon Aiyuk: Questionable (Hamstring), Deebo Samuel: Out (Foot)
    Cardinals: Josh Jones: Out (Ankle)